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KMID : 0882420100790060646
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Korean Journal of Medicine
2010 Volume.79 No. 6 p.646 ~ p.651
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Incidence of tuberculosis in Korean diabetics: Comparison with that in non-diabetic hypertensive subjects
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Park Eun-Kyoung
Bae June-Ho
Jung Yu-Min
Chung Sook-Hee
Lee Jae-Hyoung
Kim Sang-Hoon
Lee Byoung-Hoon
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Abstract
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Background/Aims : Tuberculosis remains a major cause of mortality in South Korea, and the prevalence of diabetes is also increasing rapidly. Diabetes is a well known risk factor for tuberculosis. However, the risk varies according to race and regional prevalence. We assessed the potential impact of diabetes as a risk factor for tuberculosis in South Korea.
Methods: We performed a retrospective cohort study in a secondary referral hospital. The incidence of tuberculosis in a diabetic cohort was compared with that in a non-diabetic hypertensive cohort for 6 years. Diabetics who visited our diabetic clinic and non-diabetic hypertensive patients who visited our cardiology clinic from Jan 2004 to April 2004 were assigned to the diabetic cohort and the non-diabetic hypertensive cohort, respectively. Patients in each cohort had to receive medications to control their diseases. Patients with end-stage renal disease, malignancy, or HIV infection were excluded. Relative risk and tuberculosis-free survival rates of each cohort were calculated.
Results: The incidences of tuberculosis were 32 in the diabetic cohort (n=2491; mean age, 59.1±11.8 years; 44.5% male) and ten in the non-diabetic hypertensive cohort (n=1885; mean age, 59.9±12.8 years; 41.6% male). The estimated annual incidences per 100,000 persons were 282.8 and 112.9, respectively. The relative risk was 2.220 (p=0.028; 95% confidence interval, 1.090~4.523). However, no significant difference in cumulative tuberculosis-free survival rate was observed between the cohorts (p=0.075).
Conclusions: A trend for a higher incidence of tuberculosis existed in diabetics, as compared to non-diabetic hypertensive patients, among a Korean population.
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KEYWORD
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Diabetes mellitus, Tuberculosis, Incidence
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